Article
A longitudinal 18F-FDG PET/MRI study in asymptomatic stage of genetic Creutzfeldt-Jakob disease linked to G114V mutation.
Journal of neurology - 1 Nov 2022
Chu Min, Chen Zhongyun, Nie Binbin, Liu Li, Xie Kexin, Cui Yue, Chen Kewei, Rosa-Neto Pedro, Wu Liyong
Abstract excerpt
BACKGROUND: Pathogenic prion protein may start to deposit in some brain regions and cause functional alterations in the asymptomatic stage in Creutzfeldt-Jakob disease. The study aims to determine the trajectory of the brain metabolic changes for prion protein diseases at the preclinical stage. METHODS: At baseline, we enrolled five asymptomatic PRNP G114V mutation carriers, six affected genetic PRNP E200K CJD...
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