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Article

The global succinylation of SARS-CoV-2–infected host cells reveals drug targets

12 Jul 2022

Abstract excerpt

SARS-CoV-2, the causative agent of the COVID-19 pandemic, undergoes continuous evolution, highlighting an urgent need for development of novel antiviral therapies. Here we show a quantitative mass spectrometry-based succinylproteomics analysis of SARS-CoV-2 infection in Caco-2 cells, revealing dramatic reshape of succinylation on host and viral proteins. SARS-CoV-2 infection promotes succinylation of several key...

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PMID: 35858407
DOI: 10.1073/pnas.2123065119

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