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Article

Genomic epidemiological models describe pathogen evolution across fitness valleys.

Science advances - 15 Jul 2022

Cárdenas Pablo, Corredor Vladimir, Santos-Vega Mauricio

Abstract excerpt

Genomics is fundamentally changing epidemiological research. However, systematically exploring hypotheses in pathogen evolution requires new modeling tools. Models intertwining pathogen epidemiology and genomic evolution can help understand processes such as the emergence of novel pathogen genotypes with higher transmissibility or resistance to treatment. In this work, we present Opqua, a flexible simulation...

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Identifiers

PMID: 35857510
DOI: 10.1126/sciadv.abo0173
PMCID: PMC9278859

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