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Mutation to ispA Produces Stable Small-Colony Variants of Pseudomonas aeruginosa That Have Enhanced Aminoglycoside Resistance.

Antimicrobial agents and chemotherapy - 19 Jul 2022

Pitton Melissa, Oberhaensli Simone, Appiah Fiona, Pagani Jean-Luc, Fournier Anne, Jakob Stephan M, Que Yok-Ai, Cameron David R

Abstract excerpt

Pseudomonas aeruginosa is a major pathogen in burn wound infections. We present one of the first reports of small-colony variant (SCV) emergence of P. aeruginosa, taken from a patient under aminoglycosides for a persistent burn wound infection. We confirm the causative role of a single ispA mutation in SCV emergence and increased aminoglycoside resistance. IspA is involved in the synthesis of ubiquinone,...

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Identifiers

PMID: 35852364
DOI: 10.1128/aac.00621-22
PMCID: PMC9295567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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