Article
Phenotypic and genome-wide analysis of an antibiotic-resistant small colony variant (SCV) of Pseudomonas aeruginosa.
PloS one - 1 Jan 2011
Wei Qing, Tarighi Saeed, Dötsch Andreas, Häussler Susanne, Müsken Mathias, Wright Victoria J, Cámara Miguel, Williams Paul, Haenen Steven, Boerjan Bart, Bogaerts Annelies, Vierstraete Evy, Verleyen Peter, Schoofs Liliane, Willaert Ronnie, De Groote Valérie N, Michiels Jan, Vercammen Ken, Crabbé Aurélie, Cornelis Pierre
Abstract excerpt
BACKGROUND: Small colony variants (SCVs) are slow-growing bacteria, which often show increased resistance to antibiotics and cause latent or recurrent infections. It is therefore important to understand the mechanisms at the basis of this phenotypic switch. METHODOLOGY/PRINCIPAL FINDINGS: One SCV (termed PAO-SCV) was isolated, showing high resistance to gentamicin and to the cephalosporine cefotaxime. PAO-SCV was...
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