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Article

An integrated understanding of the evolutionary and structural features of the SARS-CoV-2 spike receptor binding domain (RBD).

International journal of biological macromolecules - 30 Sept 2022

Sanyal Dwipanjan, Banerjee Suharto, Bej Aritra, Chowdhury Vaidehi Roy, Uversky Vladimir N, Chowdhury Sourav, Chattopadhyay Krishnananda

Abstract excerpt

Conventional drug development strategies typically use pocket in protein structures as drug-target sites. They overlook the plausible effects of protein evolvability and resistant mutations on protein structure which in turn may impair protein-drug interaction. In this study, we used an integrated evolution and structure guided strategy to develop potential evolutionary-escape resistant therapeutics using...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35841961
DOI: 10.1016/j.ijbiomac.2022.07.022
PMCID: PMC9278002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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