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Article

SLIT2 Rare Sequencing Variants Identified in Idiopathic Hypogonadotropic Hypogonadism.

Hormone research in paediatrics - 1 Jan 2022

Wu Jiayu, Fang Zhenghuan, Wang Xinying, Zeng Wang, Zhao Yaguang, Jiang Fang, Chen Dan-Na, Zheng Ruizhi, Li Jinchen, Men Meichao, Li Jia-Da

Abstract excerpt

INTRODUCTION: Idiopathic hypogonadotropic hypogonadism (IHH) is a rare reproductive disorder resulting from gonadotropin-releasing hormone (GnRH) deficiency. However, in only approximately half of patients with IHH is it possible to identify a likely molecular diagnosis. Mice lacking Slit2 have a reduced number or altered patterning of GnRH neurons in the brain. In order to assess the contribution of SLIT2 to...

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PMID: 35797970
DOI: 10.1159/000525769

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