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Article

Analysis of PLXNA1, NRP1, and NRP2 variants in a cohort of patients with isolated hypogonadotropic hypogonadism.

Molecular genetics & genomic medicine - 1 Nov 2021

Men Meichao, Chen Dan-Na, Li Jia-Da, Wang Xinying, Zeng Wang, Jiang Fang, Zheng Ruizhi, Dai Wenting

Abstract excerpt

BACKGROUND: Isolated hypogonadotropic hypogonadism (IHH) is a clinical syndrome described by failure of gonadal function secondary to defects on the synthesis, secretion, or action of the gonadotropin-releasing hormone (GnRH). The secreted glycoprotein SEMA3A binds its receptors NRP1 or NRP2 and PLXNA to participate in axonal projection, dendritic branching, synaptic formation, and neuronal migration. Deficiency...

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PMID: 34636164
DOI: 10.1002/mgg3.1816
PMCID: PMC8606218

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