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The Impact of D614G Mutation of SARS-COV-2 on the Efficacy of Anti-viral Drugs: A Comparative Molecular Docking and Molecular Dynamics Study.

Current microbiology - 6 Jul 2022

Poustforoosh Alireza, Hashemipour Hassan, Tüzün Burak, Azadpour Mahdiyeh, Faramarz Sanaz, Pardakhty Abbas, Mehrabani Mehrnaz, Nematollahi Mohammad Hadi

Abstract excerpt

D614G is one of the most reported mutations in the spike protein of SARS-COV-2 that has altered some crucial characteristics of coronaviruses, such as rate of infection and binding affinities. The binding affinity of different antiviral drugs was evaluated using rigid molecular docking. The reliability of the docking results was evaluated with the induced-fit docking method, and a better understanding of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35792936
DOI: 10.1007/s00284-022-02921-6
PMCID: PMC9258457

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