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Altered mitochondrial microenvironment at the spotlight of musculoskeletal aging and Alzheimer’s disease

4 Jul 2022

Abstract excerpt

Emerging evidence has linked Alzheimer's disease (AD) onset with musculoskeletal aging via a muscle-brain crosstalk mediated by dysregulation of the mitochondrial microenvironment. This study investigated gene expression profiles from skeletal muscle tissues of older healthy adults to identify potential gene biomarkers whose dysregulated expression and protein interactome were involved in AD. Screening of the...

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PMID: 35788655
DOI: 10.1038/s41598-022-15578-9

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