Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vascular defects associated with hereditary hemorrhagic telangiectasia revealed in patient-derived isogenic iPSCs in 3D vessels on chip.

Stem cell reports - 12 Jul 2022

Orlova Valeria V, Nahon Dennis M, Cochrane Amy, Cao Xu, Freund Christian, van den Hil Francijna, Westermann Cornelius J J, Snijder Repke J, Ploos van Amstel Johannes Kristian, Ten Dijke Peter, Lebrin Franck, Mager Hans-Jurgen, Mummery Christine L

Abstract excerpt

Hereditary hemorrhagic telangiectasia (HHT) is a genetic disease characterized by weak blood vessels. HHT1 is caused by mutations in the ENDOGLIN (ENG) gene. Here, we generated induced pluripotent stem cells (hiPSCs) from a patient with rare mosaic HHT1 with tissues containing both mutant (ENGc.1678C>T) and normal cells, enabling derivation of isogenic diseased and healthy hiPSCs, respectively. We showed reduced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activin Receptors, Type II
Share to Endoglin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelial Cells

Share to Induced Pluripotent Stem Cells

Share to Mutation

Share to Telangiectasia, Hereditary Hemorrhagic

Share to Tracheal and airway disorders

Share to Vascular Anomalies and Treatments

Source

Open in PubMed Open full text

Identifiers

PMID: 35777360
DOI: 10.1016/j.stemcr.2022.05.022
PMCID: PMC9287680

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vascular defects associated with hereditary hemorrhagic telangiectasia revealed in patient-derived isogenic iPSCs in 3D vessels on chip.PMID 35777360Read ↗

A Microphysiological HHT-on-a-Chip Platform Recapitulates Patient Vascular LesionsSemantic proximity Read ↗

A Microphysiological HHT-on-a-Chip Platform Recapitulates Patient Vascular LesionsSemantic proximity Read ↗

Employment of diverse in vitro systems for analyzing multiple aspects of disease, hereditary hemorrhagic telangiectasia (HHT)Semantic proximity Read ↗

Generation of ENG p.Met1Val mutant LUMCi029-A-2 for modeling Hereditary Hemorrhagic Telangiectasia type 1.Semantic proximity Read ↗

iPSC-Derived Endothelial Cells as Experimental Models for Predictive and Personalized Strategies in Cardiovascular and Cerebrovascular DiseaseSemantic proximity Read ↗

Recent Advances and Future Perspectives in Vascular Organoids and Vessel-on-ChipSemantic proximity Read ↗

ETV2 mediated differentiation of human pluripotent stem cells results in functional endothelial cells for engineering advanced vascularized microphysiological modelsSemantic proximity Read ↗

Human Induced Pluripotent Stem Cell-Derived Endothelial Cells for Three-Dimensional Microphysiological Systems.Semantic proximity Read ↗

Vascular diseases await translation of blood vessels engineered from stem cellsSemantic proximity Read ↗

High-Purity Production of Endothelial Cells from Human Pluripotent Stem CellsSemantic proximity Read ↗

Harnessing iPSCs, 3D organoids, and multiomics to model rare vascular diseases: Emerging new approach methodologies.Semantic proximity Read ↗

Applications, challenges, and prospects of induced pluripotent stem cells for vascular diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.