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Article

Antibody evolution to SARS-CoV-2 after single-dose Ad26.COV2.S vaccine in humans

18 Jun 2022

Abstract excerpt

The single-dose Ad.26.COV.2 (Janssen) vaccine elicits lower levels of neutralizing antibodies and shows more limited efficacy in protection against infection than either of the two available mRNA vaccines. In addition, Ad.26.COV.2 has been less effective in protection against severe disease during the Omicron surge. Here, we examined the memory B cell response to single-dose Ad.26.COV.2 vaccination. Compared with...

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PMID: 35776090
DOI: 10.1084/jem.20220732

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