Article
Pleiotropic effects of trans-regulatory mutations on fitness and gene expression.
Science (New York, N.Y.) - 1 Jul 2022
Vande Zande Pétra, Hill Mark S, Wittkopp Patricia J
Abstract excerpt
Variation in gene expression arises from cis- and trans-regulatory mutations, which contribute differentially to expression divergence. We compare the impacts on gene expression and fitness resulting from cis- and trans-regulatory mutations in Saccharomyces cerevisiae, with a focus on the TDH3 gene. We use the effects of cis-regulatory mutations to infer effects of trans-regulatory mutations attributable to...
Topics
- Alleles
- Evolution, Molecular
- Gene Expression
- Gene Expression Regulation, Fungal
- Genetic Fitness
- Genetic Variation
- Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)
- Mutation
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins