Article
Pleiotropic effects of trans-regulatory mutations on fitness and gene expression.
Science (New York, N.Y.) - 1 Jul 2022
Vande Zande Pétra, Hill Mark S, Wittkopp Patricia J
Abstract excerpt
Variation in gene expression arises from cis- and trans-regulatory mutations, which contribute differentially to expression divergence. We compare the impacts on gene expression and fitness resulting from cis- and trans-regulatory mutations in Saccharomyces cerevisiae, with a focus on the TDH3 gene. We use the effects of cis-regulatory mutations to infer effects of trans-regulatory mutations attributable to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.