Contributions of mutation and selection to regulatory variation: lessons from the Saccharomyces cerevisiae TDH3 gene.

Abstract excerpt

Heritable variation in gene expression is common within and among species and contributes to phenotypic diversity. Mutations affecting either cis- or trans-regulatory sequences controlling gene expression give rise to variation in gene expression, and natural selection acting on this variation causes some regulatory variants to persist in a population for longer than others. To understand how mutation and...

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