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Insights into the structural peculiarities of the N-terminal and receptor binding domains of the spike protein from the SARS-CoV-2 Omicron variant.

Computers in biology and medicine - 1 Aug 2022

Bayani Fatemeh, Safaei Hashkavaei Negin, Uversky Vladimir N, Mozaffari-Jovin Sina, Sefidbakht Yahya

Abstract excerpt

Since the new variant of SARS-CoV-2, Omicron (BA.1) has raised serious concerns, it is important to investigate the effects of mutations in the NTD and RBD domains of the spike protein for the development of COVID-19 vaccines. In this study, computational analysis of the Wuhan and Omicron NTDs and RBDs in their unbound and bound states to mAb 4A8 and ACE2 were performed. In addition, the interaction of NTD with...

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Identifiers

PMID: 35767919
DOI: 10.1016/j.compbiomed.2022.105735
PMCID: PMC9220253

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