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Article

Dynamin-2 reduction rescues the skeletal myopathy of a SPEG-deficient mouse model.

JCI insight - 8 Aug 2022

Li Qifei, Lin Jasmine, Widrick Jeffrey J, Luo Shiyu, Li Gu, Zhang Yuanfan, Laporte Jocelyn, Perrella Mark A, Liu Xiaoli, Agrawal Pankaj B

Abstract excerpt

Striated preferentially expressed protein kinase (SPEG), a myosin light chain kinase, is mutated in centronuclear myopathy (CNM) and/or dilated cardiomyopathy. No precise therapies are available for this disorder, and gene replacement therapy is not a feasible option due to the large size of SPEG. We evaluated the potential of dynamin-2 (DNM2) reduction as a potential therapeutic strategy because it has been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle, Skeletal

Share to Myopathies, Structural, Congenital

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Source

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Identifiers

PMID: 35763354
DOI: 10.1172/jci.insight.157336
PMCID: PMC9462472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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