Striated Preferentially Expressed Protein Kinase (SPEG) in Muscle Development, Function, and Disease.

Abstract excerpt

Mutations in striated preferentially expressed protein kinase (SPEG), a member of the myosin light chain kinase protein family, are associated with centronuclear myopathy (CNM), cardiomyopathy, or a combination of both. Burgeoning evidence suggests that SPEG plays critical roles in the development, maintenance, and function of skeletal and cardiac muscles. Here we review the genotype-phenotype relationships and...

Topics

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• Disease Susceptibility
• Muscle Development
• Muscle Proteins
• Muscle, Skeletal
• Myocardium