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Article

Male Marfan mice are predisposed to high-fat diet-induced obesity, diabetes, and fatty liver.

American journal of physiology. Cell physiology - 1 Aug 2022

Tiedemann Kerstin, Muthu Muthu L, Reinhardt Dieter P, Komarova Svetlana V

Abstract excerpt

Gene mutations in the extracellular matrix protein fibrillin-1 cause connective tissue disorders including Marfan syndrome (MFS) with clinical symptoms in the cardiovascular, skeletal, and ocular systems. Patients with MFS also exhibit alterations in adipose tissues, which in some individuals leads to lipodystrophy, whereas in others to obesity. We have recently demonstrated that fibrillin-1 regulates adipose...

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Identifiers

PMID: 35759435
DOI: 10.1152/ajpcell.00062.2022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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