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Plasmodium falciparum histidine-rich protein 2 and 3 gene deletion in the Mount Cameroon region

20 May 2022

Abstract excerpt

Plasmodium falciparum produces histidine-rich protein 2/3 (Pfhrp2/3) genes that accumulate to high levels in the bloodstream and serve as a diagnostic and prognostic marker for falciparum malaria. Pfhrp2/3 gene deletions may lead to false-negative rapid diagnostic test (RDT) results. We aimed to determine the prevalence of pfhrp2/3 gene deletions in P. falciparum isolates and the implications for RDT use in the...

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PMID: 35755467
DOI: 10.1016/j.ijregi.2022.05.006

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