Article
pfhrp2 and pfhrp3 Gene Deletions That Affect Malaria Rapid Diagnostic Tests for Plasmodium falciparum: Analysis of Archived Blood Samples From 3 African Countries.
The Journal of infectious diseases - 26 Sept 2019
Thomson Rebecca, Beshir Khalid B, Cunningham Jane, Baiden Frank, Bharmal Jameel, Bruxvoort Katia J, Maiteki-Sebuguzi Catherine, Owusu-Agyei Seth, Staedke Sarah G, Hopkins Heidi
Abstract excerpt
BACKGROUND: Malaria rapid diagnostic tests (mRDTs) that target histidine-rich protein 2 (HRP2) are important tools for Plasmodium falciparum diagnosis. Parasites with pfhrp2/3 gene deletions threaten the use of these mRDTs and have been reported in Africa, Asia, and South America. We studied blood samples from 3 African countries to determine if these gene deletions were present. METHODS: We analyzed 911 dried...
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