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Thymidylate Synthase Overexpression Drives the Invasive Phenotype in Colon Cancer Cells

29 May 2022

Abstract excerpt

Thymidylate synthase (TYMS) is the crucial enzymatic precursor for DNA biosynthesis and, therefore, the critical target for numerous types of chemotherapy, including the most frequently applied agent in colon cancer treatment 5-fluorouracil (5-FU). TYMS also seems to be associated with cancer metastasis and acquiring mesenchymal character by tumor cells during epithelial-mesenchymal transition (EMT). Based on...

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PMID: 35740289
DOI: 10.3390/biomedicines10061267

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