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Article

Clearance of atypical cutaneous manifestations of hyper-IgE syndrome with dupilumab.

Pediatric dermatology - 1 Nov 2022

Nihal Aman, Comstock Jeanette R, Holland Kristen E, Singh Anne Marie, Seroogy Christine M, Arkin Lisa M

Abstract excerpt

Hyper-IgE syndromes (HIES) are a heterogeneous group of rare primary immunodeficiency diseases classically characterized by the triad of atopic dermatitis, and recurrent cutaneous and pulmonary infections. Autosomal dominant, loss-of-function STAT3 pathogenic variants are the most common genetic cause, which lead to deficiency of Th17 lymphocytes, impaired interferon gamma production, and IL-10 signal...

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PMID: 35734823
DOI: 10.1111/pde.15072
PMCID: PMC10084161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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