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Article

Pediatric IPEX-Associated Dermatitis Responds To Dupilumab: Evidence from Skin Transcriptomics and Immune Profiling.

Journal of clinical immunology - 7 Feb 2026

Yang Jinxiang, Li Guofang, Zhang Jiayan, Wang Jiao, Yang Yijun, Guo Qiuyang, Yan Kexin, Hu Haoyang, Xue Jiayi, Ma Yiming, Liang Jianying, Yao ZhiRong, Zhang Hui, Li Chunxiao

Abstract excerpt

PURPOSE: Immunodysregulation, Polyendocrinopathy, Enteropathy, and X-linked (IPEX) syndrome is a rare autoimmune disorder caused by mutations in the FOXP3 gene. Patients with IPEX frequently present with severe dermatitis, diabetes, and enteropathy. This study explores the efficacy of Dupilumab (an anti-IL-4Rα monoclonal antibody) in treating persistent, severe dermatitis in an IPEX patient refractory to...

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Share to Antibodies, Monoclonal, Humanized
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41653277
DOI: 10.1007/s10875-025-01979-8
PMCID: PMC12923480

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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