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Article

Production, characterization and immunogenicity of P particles derived from norovirus GII.4 genotype 2004 variant.

Acta virologica - 1 Mar 2015

Su W, Gao J, Zang Y, Wu H, Wang L, Hu H, Yu X, Kong W, Jiang C

Abstract excerpt

Norovirus (NoV) is the main cause of nonbacterial infectious gastroenteritis. Due to the difficulty of culturing the virus, research on vaccine against NoV is focused on virus-like particles (VLPs). On the other hand, the P particles assembled from the P domains of NoV capsid protein become a promising vaccine candidate. GII.4 is the most prevalent genotype of NoV. While the immunogenicity of P particles derived...

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PMID: 25790049
DOI: 10.4149/av_2015_01_33

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