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Article

YAP1 is essential for malignant mesothelioma tumor maintenance

10 Jun 2022

Abstract excerpt

Malignant pleural mesothelioma, a tumor arising from the membrane covering the lungs and the inner side of the ribs, is a cancer in which genetic alterations of genes encoding proteins that act on or are part of the Hippo-YAP1 signaling pathway are frequent. Dysfunctional Hippo signaling may result in aberrant activation of the transcriptional coactivator protein YAP1, which binds to and activates transcription...

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PMID: 35689194
DOI: 10.1186/s12885-022-09686-y

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