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Extracellular release of two peptidases dominates generation of the trypanosome quorum-sensing signal

9 Jun 2022

Abstract excerpt

Trypanosomes causing African sleeping sickness use quorum-sensing (QS) to generate transmission-competent stumpy forms in mammalian hosts. This density-dependent process is signalled by oligopeptides that stimulate the signal transduction pathway leading to stumpy formation. Here, using mass spectrometry analysis, we identify peptidases released by trypanosomes and, for 12 peptidases, confirm their extracellular...

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PMID: 35680928
DOI: 10.1038/s41467-022-31057-1

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