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Article

Genetic Determinants of Body Mass Index and Fasting Glucose Are Mediators of Grade 1 Diastolic Dysfunction.

Journal of the American Heart Association - 7 Jun 2022

Vaitinadin Nataraja Sarma, Shi Mingjian, Shaffer Christian M, Farber-Eger Eric, Lowery Brandon D, Agrawal Vineet, Gupta Deepak K, Roden Dan M, Wells Quinn S, Mosley Jonathan D

Abstract excerpt

Background Early (grade 1) cardiac left ventricular diastolic dysfunction (G1DD) increases the risk for heart failure with preserved ejection fraction and may improve with aggressive risk factor modification. Type 2 diabetes, obesity, hypertension, and coronary heart disease are associated with increased incidence of diastolic dysfunction. The genetic drivers of G1DD are not defined. Methods and Results We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35656995
DOI: 10.1161/JAHA.122.025578
PMCID: PMC9238715

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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