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Article

Estimation of familial recurrence risk of malignancy: Application of liability threshold model in genetic counseling.

Clinical genetics - 1 Sept 2022

Nagao Yoshiro

Abstract excerpt

Apart from some Mendelian-inherited tumors, malignancies are multifactorial diseases, and reported data are often the only sources to estimate familial recurrence risk. Edwards' approximation formula has provided one way forward, but it uses estimates only from incidence in the general population, and is thus too simple to be widely utilized for complex individual instances. On the other hand, the heritability of...

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PMID: 35652326
DOI: 10.1111/cge.14171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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