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Article

Mutation Screening of TFG in α-Synucleinopathy and Amyotrophic Lateral Sclerosis.

Movement disorders : official journal of the Movement Disorder Society - 1 Aug 2022

Li Chunyu, Lin Junyu, Gu Xiaojing, Hou Yanbing, Liu Kuncheng, Jiang Qirui, Ou Ruwei, Wei Qianqian, Chen Xueping, Song Wei, Zhao Bi, Wu Ying, Chen Yongping, Shang Huifang

Abstract excerpt

BACKGROUND: Recently, p.R383H in TFG was identified as the disease cause in a family with α-synucleinopathy and amyotrophic lateral sclerosis (ALS). However, no further replication has been conducted in larger cohorts. OBJECTIVE: The aim was to explore the genetic role of TFG in α-synucleinopathy and ALS. METHODS: We analyzed the rare protein-coding variants in patients with Parkinson's disease (PD), ALS,...

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PMID: 35642252
DOI: 10.1002/mds.29079

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