Integration of human inspection and artificial intelligence‐based morphological typing of patient‐derived organoids reveals interpatient heterogeneity of colorectal cancer

Abstract excerpt

Colorectal cancer (CRC) is a heterogenous disease, and patients have differences in therapeutic response. However, the mechanisms underlying interpatient heterogeneity in the response to chemotherapeutic agents remain to be elucidated, and molecular tumor characteristics are required to select patients for specific therapies. Patient-derived organoids (PDOs) established from CRCs recapitulate various biological...

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