Article
A highland-adaptation mutation of the Epas1 protein increases its stability and disrupts the circadian clock in the plateau pika.
Cell reports - 17 May 2022
Liu Na, Tian Hongni, Yu Ziqing, Zhao Haijiao, Li Wenjing, Sang Di, Lin Keteng, Cui Yilin, Liao Meimei, Xu Zhancong, Chen Chen, Guo Ying, Wang Yibing, Huang Huan-Wei, Wang Jiawen, Zhang He, Wu Wei, Huang He, Lv Shengqing, Guo Zhenqian, Wang Wei, Zheng Sanduo, Wang Fengchao, Zhang Yanming, Cai Tao, Zhang Eric Erquan
Abstract excerpt
The Qinghai-Tibet Plateau (QTP) harbors hundreds of species well adapted to its extreme conditions, including its low-oxygen (hypoxic) atmosphere. Here, we show that the plateau pika-a keystone mammal of the QTP-lacks robust circadian rhythms. The major form of the plateau pika Epas1 protein includes a 24-residue insert caused by a point mutation at the 5' juncture site of Intron14 and is more stable than other...
Topics
- Acclimatization
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Circadian Clocks
- Circadian Rhythm
- Hypoxia
- Lagomorpha
- Mice
- Mutation