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Proteomic characterization of Omicron SARS-CoV-2 host response

18 May 2022

Abstract excerpt

Since its first reported case in November 2021 in South Africa 1 , the novel SARS-CoV-2 variant Omicron infection has swept across the world. The Omicron variant has over 30 mutations in the spike (S) protein which increase its affinity for ACE2 but decrease the cleavage efficiency of S protein by TMPRSS2, leading to suppressed virulence and reduced replication 2 . Furthermore, a population-scale meta-analysis...

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PMID: 35581179
DOI: 10.1038/s41421-022-00418-x

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