Article
Toll-Like Receptor Signaling in the Pathogenesis of Chronic Dacryocystitis: Implication of c-FOS Transcription Factor and its Downstream Effector Chemokine Genes CCL2, CCL4, CXCL3, CXCR4 with a Shift of the M1/M2 Macrophage Phenotype.
Combinatorial chemistry & high throughput screening - 1 Jan 2023
Edris Noha Ahmed, Aboulhoda Basma Emad, El-Din Shimaa Saad, Fouad Amina Mahmoud, Albadawi Emad, Rashed Laila Ahmed, Elessawy Kareem Bakr
Abstract excerpt
INTRODUCTION: TLRs are fundamental elements in the orchestration of the innate immune system. These receptors seem to be responsible for the inflammation and fibrosis in chronic dacryocystitis. The aim of the present study was to investigate the role of the toll-Like receptors (TLR2 and TLR4) signaling pathway and its downstream effector chemokine genes in the pathogenesis of chronic dacryocystitis. METHODS: This...
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