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Article

Tumor mutational burden presents limiting effects on predicting the efficacy of immune checkpoint inhibitors and prognostic assessment in adrenocortical carcinoma.

BMC endocrine disorders - 14 May 2022

Xu Fangshi, Guan Yibing, Zhang Peng, Xue Li, Ma Yubo, Gao Mei, Chong Tie, Ren Bin-Cheng

Abstract excerpt

BACKGROUND: Adrenocortical carcinoma (ACC) is a highly malignant urologic cancer and tends to metastasize. Although immune checkpoint inhibitors (ICIs) bring a glimmer of light to conquer ACC, only a fraction of patients have benefit from ICIs treatment. It is well known that tumor mutational burden (TMB) is closely associated with the efficacy and response rate of immunotherapy. However, its roles in ACC were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35568842
DOI: 10.1186/s12902-022-01017-3
PMCID: PMC9107278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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