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Article

Spatial transcriptomics uncovers the hybrid molecular identity, ciliated phenotype, and immune signature of adenomyosis lesions.

Science advances - 26 Jun 2026

Maclean Alison, Johnson Emily, Rushworth Corie, Hill Christopher J, Caamaño Gutiérrez Eva, Hapangama Dharani K

Abstract excerpt

Adenomyosis is a common gynecological condition characterized by ectopic endometrial-like tissue deep within the myometrium, causing debilitating symptoms. Treatment options are limited to hormones that primarily focus on symptom management only or invasive hysterectomy. Despite its prevalence, the pathogenesis of adenomyosis remains poorly understood, considerably impeding the development of targeted, true...

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Identifiers

PMID: 42341108
DOI: 10.1126/sciadv.aea6379
PMCID: PMC13292934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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