Article
Characterization of EPO H131S as a key mutation site in the hypoxia-adaptive evolution of Gymnocypris dobula.
Fish physiology and biochemistry - 1 Jun 2022
Wang Congcong, Zhang Qin, Liu Yang, Xu Qianghua
Abstract excerpt
Erythropoietin (EPO) is a glycoprotein hormone involved in proerythropoiesis, antioxidation, and antiapoptosis. It also contributes to cellular immune function in high-altitude species, such as the schizothoracine fish Gymnocypris dobula. Six mutation sites previously identified in EPO from G. dobula (GD-EPO) were injected into zebrafish embryos, and their effects were compared with EPO from the low-altitude...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.