Article
Staphylococcus aureus Does Not Synthesize Arginine from Proline under Physiological Conditions.
Journal of bacteriology - 21 Jun 2022
Jeong Bohyun, Shah Majid Ali, Roh Eunjung, Kim Kyeongkyu, Park Indal, Bae Taeok
Abstract excerpt
The Gram-positive pathogen Staphylococcus aureus is the only bacterium known to synthesize arginine from proline via the arginine-proline interconversion pathway despite having genes for the well-conserved glutamate pathway. Since the proline-arginine interconversion pathway is repressed by CcpA-mediated carbon catabolite repression (CCR), CCR has been attributed to the arginine auxotrophy of S. aureus. Using...
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