Article
CcpA regulates arginine biosynthesis in Staphylococcus aureus through repression of proline catabolism.
PLoS pathogens - 1 Jan 2012
Nuxoll Austin S, Halouska Steven M, Sadykov Marat R, Hanke Mark L, Bayles Kenneth W, Kielian Tammy, Powers Robert, Fey Paul D
Abstract excerpt
Staphylococcus aureus is a leading cause of community-associated and nosocomial infections. Imperative to the success of S. aureus is the ability to adapt and utilize nutrients that are readily available. Genomic sequencing suggests that S. aureus has the genes required for synthesis of all twenty amino acids. However, in vitro experimentation demonstrates that staphylococci have multiple amino acid auxotrophies,...
Topics
- Abscess
- Animals
- Bacterial Proteins
- Disease Models, Animal
- Genome, Bacterial
- Kidney Diseases
- Mice
- Mutation
- Proline
- Staphylococcal Infections
- Staphylococcus aureus
- Transcription Factors