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Germline MUTYH mutations and high‐grade gliomas: Novel evidence for a potential association

12 May 2022

Abstract excerpt

There is growing body of evidence supporting the role of germline mutations in the pathogenesis of pediatric central nervous system (CNS) tumors, and the widespread use of next-generation sequencing (NGS) panels facilitates their detection. Variants of the MUTYH gene are increasingly recognized as suspected germline background of various extraintestinal malignancies, besides their well-characterized role in the...

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PMID: 35545820
DOI: 10.1002/gcc.23054

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