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CD9 expression in porcine blood CD4+ T cells delineates two subsets with phenotypic characteristics of central and effector memory cells.

Developmental and comparative immunology - 1 Aug 2022

Álvarez Belén, Revilla Concepción, Moreno Sara, Jiménez-Marín Ángeles, Ramos Elena, Martínez de la Riva Paloma, Poderoso Teresa, Garrido Juan J, Ezquerra Ángel, Domínguez Javier

Abstract excerpt

In this report, we describe the characterization of a new monoclonal antibody, named 4H5CR4, against porcine CD9. Its use in combination with antibodies to CD4, CD8α, and 2E3 allows to distinguish at least five main CD4+ T cell subsets. Analysis on these subsets of CD45RA, CD27, CD29, CD95, CCR7, and SLA-DR markers depicts a progressive model of CD4+ T cell development. CD4+ 2E3+ CD8α- CD9- cells are the least...

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PMID: 35526640
DOI: 10.1016/j.dci.2022.104431

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