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Article

Neurotransmitter phenotype switching by spinal excitatory interneurons regulates locomotor recovery after spinal cord injury.

Nature neuroscience - 1 May 2022

Bertels Hannah, Vicente-Ortiz Guillem, El Kanbi Khadija, Takeoka Aya

Abstract excerpt

Severe spinal cord injury in adults leads to irreversible paralysis below the lesion. However, adult rodents that received a complete thoracic lesion just after birth demonstrate proficient hindlimb locomotion without input from the brain. How the spinal cord achieves such striking plasticity remains unknown. In this study, we found that adult spinal cord injury prompts neurotransmitter switching of spatially...

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Identifiers

PMID: 35524138
DOI: 10.1038/s41593-022-01067-9
PMCID: PMC9076533

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