Article
Prognostic significance of dynamin-related protein 1 expression in advanced lung adenocarcinoma.
Pathology, research and practice - 1 Jun 2022
Huang Yen-Lin, Chen Yi-Jung, Juan Yi-Hsiu, Wu Shang-Gin, Chung Kuei-Pin
Abstract excerpt
BACKGROUND: Dynamin-related protein 1 (DRP1) is a key regulator of mitochondrial fission and is activated by phosphorylation at serine 616. We previously demonstrated that DRP1 activation is regulated by epidermal growth factor receptor (EGFR) signaling and multiple kinases in lung adenocarcinoma, and is significantly associated with an increased risk of postoperative recurrence in early stage lung...
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