Article
Variance of allele balance calculated from low coverage sequencing data infers departure from a diploid state.
BMC bioinformatics - 25 Apr 2022
Fletcher Kyle, Han Rongkui, Smilde Diederik, Michelmore Richard
Abstract excerpt
BACKGROUND: Polyploidy and heterokaryosis are common and consequential genetic phenomena that increase the number of haplotypes in an organism and complicate whole-genome sequence analysis. Allele balance has been used to infer polyploidy and heterokaryosis in diverse organisms using read sets sequenced to greater than 50× whole-genome coverage. However, sequencing to adequate depth is costly if applied to...
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