Article
Effects of the SLICK1 mutation in PRLR on regulation of core body temperature and global gene expression in liver in cattle.
Animal : an international journal of animal bioscience - 1 May 2022
Sosa Froylan, Santos José E P, Rae D Owen, Larson Colleen C, Macchietto Marissa, Abrahante Juan E, Amaral Thiago F, Denicol Anna C, Sonstegard Tad S, Hansen Peter J
Abstract excerpt
The SLICK1 mutation in bovine PRLR (c.1382del; rs517047387) is a deletion mutation resulting in a protein with a truncated intracellular domain. Cattle carrying at least one allele have a phenotype characterized by a short hair coat (slick phenotype) and increased resistance to heat stress. Given the pleiotropic nature of prolactin, the mutation may affect other physiological characteristics. The liver is one...
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