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Article

Changes in adiposity modulate the APOA5 genetic effect on blood lipids: A longitudinal cohort study.

Atherosclerosis - 1 Jun 2022

Lin Hong, Xuan Liping, Xiang Jiali, Hou Yanan, Dai Huajie, Wang Tiange, Zhao Zhiyun, Wang Shuangyuan, Lu Jieli, Xu Yu, Chen Yuhong, Wang Weiqing, Ning Guang, Bi Yufang, Li Mian, Xu Min

Abstract excerpt

BACKGROUND AND AIMS: The Apolipoprotein A5 (APOA5) rs662799 was significantly associated with blood lipid level at genome-wide significance level. Whether dynamic changes of adiposity influence the effect of lipid loci on long-term blood lipid profile remains unclear. We assessed interactions of 5-year body mass index (BMI) change and rs662799 genotypes with risk of incident dyslipidemia and longitudinal changes...

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Identifiers

PMID: 35461093
DOI: 10.1016/j.atherosclerosis.2022.03.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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