Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of KIF23 Alleviates IPAH by Targeting Pyroptosis and Proliferation of PASMCs

18 Apr 2022

Abstract excerpt

Idiopathic pulmonary arterial hypertension (IPAH) is a progressive vascular disease with high mortality and heritability. Pyroptosis is a novel form of programmed cell death, and it is closely associated with IPAH. However, the roles of pyroptosis-related genes (PRGs) in IPAH are still largely unknown. In this study, we identified KIF23 as the most relevant gene for IPAH and pyroptosis, and its expression was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gout, Hyperuricemia, Uric Acid
Share to Inflammasome and immune disorders
Share to Pulmonary Hypertension Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35457254
DOI: 10.3390/ijms23084436

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of KIF23 Alleviates IPAH by Targeting Pyroptosis and Proliferation of PASMCsPMID 35457254Read ↗

Identification of Potential Risk Genes and the Immune Landscape of Idiopathic Pulmonary Arterial Hypertension via Microarray Gene Expression Dataset Reanalysis.Semantic proximity Read ↗

PINK1-mediated Mitophagy Contributes to Pulmonary Vascular Remodeling in Pulmonary HypertensionSemantic proximity Read ↗

Identification of Crucial Hub Genes and Differential T Cell Infiltration in Idiopathic Pulmonary Arterial Hypertension Using Bioinformatics StrategiesSemantic proximity Read ↗

Analysis of communal Pathogenesis and Immune Infiltration Characteristics Between Psoriasis and Pulmonary Arterial HypertensionSemantic proximity Read ↗

A new integrative analysis of histopathology and single cell RNA-seq reveals the CCL5 mediated T and NK cell interaction with vascular cells in idiopathic pulmonary arterial hypertensionSemantic proximity Read ↗

Regulation of pyroptosis in cardiovascular pathologies: Role of noncoding RNAsSemantic proximity Read ↗

PTBP1 Targets ILK to Regulate the Hypoxia-Induced Phenotypic Transformation of Pulmonary Artery Smooth Muscle Cells.Semantic proximity Read ↗

Novel hub genes associated with pulmonary artery remodeling in pulmonary hypertensionSemantic proximity Read ↗

Involvement of Alveolar Epithelial Cell Necroptosis in Idiopathic Pulmonary Fibrosis PathogenesisSemantic proximity Read ↗

Integrated Bioinformatic Analysis Reveals TXNRD1 as a Novel Biomarker and Potential Therapeutic Target in Idiopathic Pulmonary Arterial HypertensionSemantic proximity Read ↗

Hypoxia activates GPR146 which participates in pulmonary vascular remodeling by promoting pyroptosis of pulmonary artery endothelial cellsSemantic proximity Read ↗

Updated perspective of EPAS1 and the role in pulmonary hypertensionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.