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Autophagy in Rheumatic Diseases: Role in the Pathogenesis and Therapeutic Approaches

15 Apr 2022

Abstract excerpt

Autophagy is a lysosomal pathway for the degradation of damaged proteins and intracellular components that promotes cell survival under specific conditions. Apoptosis is, in contrast, a critical programmed cell death mechanism, and the relationship between these two processes influences cell fate. Recent evidence suggests that autophagy and apoptosis are involved in the self-tolerance promotion and in the...

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PMID: 35456038
DOI: 10.3390/cells11081359

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