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Knockout mouse models of sperm flagellum anomalies

24 Mar 2006

Abstract excerpt

To date, 21 knockout mouse models are known to bear specific anomalies of the sperm flagellum structures leading to motility disorders. In addition, genes responsible for flagellar defects of two well-known spontaneous mutant mice have recently been identified. These models reveal genetic factors, which are required for the proper assembly of the axoneme, the annulus, the mitochondrial sheath and the fibrous...

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PMID: 16565154
DOI: 10.1093/humupd/dml013

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