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Estradiol deficiency reduces the satellite cell pool by impairing cell cycle progression

20 Apr 2022

Abstract excerpt

The size of the satellite cell pool is reduced in estradiol (E2)-deficient female mice and humans. Here, we use a combination of in vivo and in vitro approaches to identify mechanisms, whereby E2 deficiency impairs satellite cell maintenance. By measuring satellite cell numbers in mice at several early time points postovariectomy (Ovx), we determine that satellite cell numbers decline by 33% between 10 and 14...

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PMID: 35442828
DOI: 10.1152/ajpcell.00429.2021

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