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Article

Prognostic impact of copy number alterations and tumor mutational burden in carcinoma of unknown primary.

Genes, chromosomes & cancer - 1 Sept 2022

Bochtler Tilmann, Wohlfromm Timothy, Hielscher Thomas, Stichel Damian, Pouyiourou Maria, Kraft Bianca, Neumann Olaf, Endris Volker, von Deimling Andreas, Stenzinger Albrecht, Krämer Alwin

Abstract excerpt

INTRODUCTION: Chromosomal aberrations are known to drive metastatic spread, but their profile is still elusive in carcinoma of unknown primary (CUP). Therefore, the aim of this study was to characterize the chromosomal aberration pattern in CUP depending on histological and clinical features and to assess its prognostic impact together with chromothripsis, tumor mutational burden (TMB), microsatellite instability...

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PMID: 35430765
DOI: 10.1002/gcc.23047

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